Environmental toxins, from airborne particulate matter and industrial pollutants to chemical contaminants, affect nearly every organ system in the body. Research over the past decade has shown strong associations between environmental exposures and a wide range of diseases, including lung injury and chronic respiratory disorders, cardiovascular disease, neuroinflammatory and neurodegenerative conditions, immune dysregulation, endocrine and thyroid dysfunction, reproductive and developmental abnormalities, and multiple cancers such as those of the hematopoietic system and prostate. These exposures trigger inflammation, oxidative stress, DNA damage, and metabolic disruption, creating a biologic environment that promotes tissue dysfunction and disease susceptibility. Our lab is dedicated to uncovering the mechanisms linking toxic exposures to human disease and developing strategies to reduce their impact on vulnerable populations.